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F2 lora of China 4: 97–101 Although banned by the NFL, NCAA and International Olympic Committee, dietary supplements containing ephedrine are still consumed by athletes and the general public, often in the hopes that it will aid weight loss or provide a stimulant-induced performance edge. To find out the latest on this common dietary supplement, we asked Ellen Coleman, RD, MA, MPH, a nutrition consultant for the Los Angeles Lakers and Anaheim Angels, to research the most current findings regarding this drug.
We hope you find this information useful.
Bob Murray, PhD, FACSM
Director, Gatorade Sports Science Institute
Ephedrine-Containing Supplements
April, 2003
Ellen Coleman, RD, MA, MPH
In many competitions, the difference between winning and losing can occur in one play or the divisions of seconds. So it is not surprising that athletes may want to utilize ephedrine-containing supplements to improve their performance, have more energy or decrease their body fat. Unfortunately, athletes who use ephedrine may risk getting more than they bargained for from the drug. While it may help them run farther and faster, it can also make them prey to the myriad of negative—even potentially life-threatening—side effects. The fact is ephedrine use is controversial at best. Especially when you consider that the NFL, NCAA and International Olympic Committee have all taken steps to keep it off the playing fields. And now, the FDA is getting into the discussion.
What is Ephedrine
So what exactly is ephedrine? Classified as a sympathomimetic drug (a beta-1 and beta-2 adrenergic receptor agonist), it’s a central nervous system stimulant that increases serum levels of norepinephrine. The herbs ma huang, ephedra sinica and Sida cordifolia contain ephedrine, which structurally is similar to amphetamines.1
Ephedrine is an effective bronchodilator due to its stimulation of beta–2 receptors in the lungs. However, it also stimulates beta-1 receptors in the heart and causes dose-dependent increases in heart rate and blood pressure. Drugs that are more selective beta-2 agonists are generally preferred for treatment of asthma.1
Ephedrine’s Role in Athletic Performance and Weight Loss
Ephedrine’s appeal to users rests in the fact that it may do one or all of the following three things, depending on the individual:
Improve athletic performance by stimulating the central nervous system and by increasing heart rate and contraction force via activation of the beta-1 receptors.
Suppress appetite by increasing norepinephrine release through stimulation of adrenergic pathways in the hypothalamus.1
Promote weight loss by increasing thermogenesis and resting energy expenditure via stimulation of the muscle beta-2 receptors to increase substrate metabolism.
Combining the drug with caffeine and aspirin (called the "ECA stack"), as some users do in the belief that it will enhance its effectiveness as a weight loss agent, may add significantly to the risk. In this context, ephe