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Xenadrine with ephedra avandia baycol benzene bextra disability enbrel ephedra ephedrine fen-phen lariam lotronex manganese meridia medical insurance fraud lawsuits. drine stimulates the release of norepinephrine, which stimulates the release of adenosine and the synthesis of prostaglandins by the activated tissue. Adenosine and prostaglandins both inhibit the effect of norepinephrine. Caffeine opposes the effect of adenosine and so increases norepinephrine release. Aspirin inhibits the synthesis of prostaglandins and so enhances the effect of norepinephrine.1 Side Effects What users may not understand or take seriously when they seek the performance enhancing benefits of the supplement are the adverse effects it can produce. Ephedrine raises heat production and body temperature and may increase the athlete’s risk of developing a heat injury during exercise in warm weather. In addition to increased heat production, other effects may include dizziness, headache, gastrointestinal distress, irregular heartbeat, and heart palpitations to heart attack, stroke, seizures, psychosis and even death. These side effects can vary among individuals and occasions and don't always depend on how much is consumed. Also, combining caffeine (from coffee, Guarana, mate, or any other source) with ephedrine-containing products (such as those mentioned earlier) greatly increases the risks.2,3 If the knowledge of these adverse effects isn’t enough to deter users, the International Olympic Committee, the National Collegiate Athletic Association (NCAA) and the National Football League (NFL) are hoping some of their recent policies banning the drug—and suspending players for doping—will be. Research Findings Still, are these organizations’ concerns about ephedrine really valid? 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